Insulin Secretion

Insulin Secretion

Insulin is secreted from the -cells of the pancreatic islets by Ca 2 -dependent exocytosis of large dense core vesicles (LDCVs) (Ämmälä et al., 1993), a process that is triggered by glucose-induced electrical activity (Henquin and Meissner, 1984). In response to a step elevation of glucose, insulin secretion follows a characteristic biphasic time course (Curry et al., 1968): an initial transien...

Insulin Secretion and Actions

Islet Biology/Insulin Secretion

duces proinflammatory lipids that exacerbate β cell dysfunction and death. Inhibition of 12/15-LOX thereby provides a potential therapeutic approach to prevent glycemic deterioration in T1D, but to date no specific inhibitors have been tested T1D. Here we assessed the efficacy and mechanism of a novel and specific 12/15-LOX inhibitor, ML351. Using cultured β cells in vitro, ML351 exhibited no a...

Aging and insulin secretion.

Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes and postchallenge hyperglycemia in the older population. Age-related glucose intolerance in humans is often accompanied by insulin resistance, but circulating insulin levels are similar to those of younger people. Under some conditions of hyperglycemic challenge, insulin levels are lower in olde...

Bromocriptine and insulin secretion.

The dopaminergic drug bromocriptine inhibited the release of insulin from isolated mouse pancreatic islets. The effect was counteracted by haloperidol or pimozide. It is suggested that insulin release may be inhibited through activation of D-2 dopaminergic receptors in the pancreatic beta-cells.